Fig. 4
From: Unique molecular signature in mucolipidosis type IV microglia
Comparison of microglia transcriptomes in diseases with neuroinflammation. a Volcano plot differentially expressed genes X = Log2 fold change vs control, Y = − Log10(p). The data are supplied in Additional file 7: Table S3. The dashed lines are set at the pAdj of 0.05 and Log2 fold change of – 1 and 1 on Y- and X-axis, respectively. b Venn diagram of the significantly differentially expressed genes (pAdj < 0.05, Log2FC > 1) genes in ALS (SOD1), AD (APP), NPC1, and MLIV disease mouse models. c Heatmap of the 100 modified genes AD, ALS, MLIV, and NPC1 diseases across aging (aged and ERCC1) and FD datasets. Yellow: DAM markers. Orange: HIF1 signaling. Blue: lysosome. The heatmap with all genes labeled is provided in Additional file 4: Figure S4a