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Table 1 Advantages and disadvantages of the detection of biomarkers in blood and cerebrospinal fluid; modified according to [33, 34]

From: Molecular biomarkers in multiple sclerosis

Blood• Safe, quick, and easy collection
• Different timepoints could be measured
• Quite large quantities can be analyzed
• Does not necessarily reflect changes in the CNS
• Diurnal variation of many soluble markers
• Markers affected by a lot of processes (degradation, concomitant disease…)
• Potential preanalytical bias
• Lower concentration of potential biomarker
Cerebrospinal fluid• Best reflects the processes in the CNS
• Lower concentration of potential biomarker
• Exposure to invasive lumbar puncture
• Only low quantities can be obtained
• Difficult to measure different timepoints
• Potential preanalytical bias