Fig. 4.

Effect of FH deficiency on bacterial outgrowth, complement, and inflammatory response during experimental pneumococcal meningitis. Bacterial outgrowth in CSF, brain, blood, lung, and spleen of Cfh^−/− and wt mice at 20 h after infection (a). Plasma and brain C3 levels were decreased in Cfh^−/− mice compared to wt mice at 5 and 20 h after infection (b). Cfh^−/− mice had significantly lower cytokine and chemokine brain levels at 5 h after infection and significant higher cytokine and chemokine brain levels at 20 h after infection (c). Data are given as medians and interquartile ranges, P values were determined with the Mann-Whitney U test