From: Complement factor H contributes to mortality in humans and mice with bacterial meningitis
Clinical characteristics | n/N (%) |
---|---|
Age (years) | 60 (45–69) |
Male | 509 (49%) |
Predisposing conditions | 580/1009 (57%) |
 Otitis or sinusitis | 329/1007 (24%) |
 Pneumonia | 90/975 (9%) |
 Immunocompromised state b) | 258/1009 (26%) |
Symptoms and signs at admission | |
 Symptoms < 24 h | 452/973 (46%) |
 Headache | 742/891 (83%) |
 Neck stiffness | 722/956 (76%) |
 Temp > 38 °C | 757/1002 (76%) |
Score on Glasgow coma scale c) | 11 (9–14) |
 < 8 indicating coma | 135/1008 (13%) |
CSF values d) | |
 White blood cell count (/μl) | 2497 (561–7561) |
 Protein (g/l) | 3.82 (2.30–5.99) |
 CSF/blood glucose ratio | 0.03 (0.00–0.25) |
Causative pathogen | |
 S. pneumoniae | 727 (72%) |
 N. meningitidis | 111 (11%) |
 Other | 171 (17%) |
Score on Glasgow outcome scale | |
 1—death | 182 (18%) |
 2—vegetative state | 1 (0.1%) |
 3—severe disability | 48 (5%) |
 4—moderate disability | 160 (16%) |
 5—good recovery | 618 (61%) |