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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells

Fig. 3

Comparison of phenotype of CTLs located in the spleen and CNS in EAE. At day 14 post-EAE induction, CD8 T cells from the spleen and from CNS-infiltrating cells were isolated and incubated with irradiated syngeneic splenocytes loaded with 1 μM of peptide (MOG35–55, MOG37–50, or gp10025–33 control peptide) for 48 h in the presence of 20 pg/ml IL-2. Granzyme B (a), IFNγ (b), and TNF (c) levels were quantified by ELISA in the cell supernatant of stimulated inflammatory T cells. n = 5 mice/group; data shown as mean ± standard error. *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001 (two-way ANOVAs followed by Tukey’s post hoc test)

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