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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Fig. 4

Sensory and motor functions recover faster in SIRPα−/− mice than in wild-type mice. The a flexor-withdrawal reflex and b toe-spreading reflex recovery curves display the cumulative percentage of mice that regained (a) sensory and (b) motor functions at each of the indicated days after surgery. a Sensory function was tested in 14 wild-type (WT) and 11 SIRPα−/− mice. Significance of difference of WT mice from SIRPα−/− mice, p < 0.001, by the log-rank Mantel-Cox test. b Motor function was tested in 12 wild-type (WT) and 11 SIRPα−/− mice using the toe-spreading reflex. Significance of difference of wild-type mice from SIRPα−/− mice, p < 0.01, by the log-rank Mantel-Cox test.

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Journal of Neuroinflammation

ISSN: 1742-2094