Serum dickkopf-3 is associated with death and vascular events after ischemic stroke: an observational study from CATIS

Table 2 Reclassification and discrimination statistics for adverse clinical outcomes by serum Dkk-3 among ischemic stroke patients

Clinical outcomes	Model	Continuous NRI, %		IDI, %
Clinical outcomes	Model	Estimate (95% CI)	p value^†	Estimate (95% CI)	p value^†
Death or vascular events	Conventional model
Death or vascular events	Conventional model + aberrant serum Dkk-3 levels^*	28.44 (17.99–38.88)	< 0.001	0.48 (0.19–0.77)	0.001
Death	Conventional model
Death	Conventional model + aberrant serum Dkk-3 levels^*	28.81 (15.96–41.66)	< 0.001	0.40 (− 0.33–1.12)	0.282
Vascular events	Conventional model
Vascular events	Conventional model + aberrant serum Dkk-3 levels^*	24.95 (11.60–38.29)	< 0.001	0.30 (0.17–0.44)	< 0.001

Conventional Cox proportional hazards regression model included age, sex, time from onset to hospitalization, current smoking, alcohol consumption, dyslipidemia, body mass index, blood glucose, diastolic blood pressure, creatinine, high sensitivity C-reactive protein, baseline NIHSS score, history of hypertension, history of coronary heart disease, history of diabetes mellitus, family history of stroke, ischemic stroke subtypes, and receiving immediate blood pressure reduction
CI confidence interval, Dkk-3 dickkopf-3, IDI integrated discrimination improvement, NRI net reclassification improvement
*The aberrant serum Dkk-3 levels were defined as the low or high levels of serum Dkk-3 (first, second, fourth, and fifth quintile of Dkk-3)
^†p values were based on the asymptotic test

ISSN: 1742-2094