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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1+ stem cells from young donors

Fig. 3

Young Sca-1+ stem cells upregulate several dopamine-dependent memory genes and preserve neuronal numbers in the locus coeruleus. a Significantly dysregulated genes organized according to function and significance using Gene Ontology (Y+-O vs. Y-O) for n = 3 animals per group. b Verification of several significantly upregulated memory genes using RTqPCR for n = 5 animals per group. c Immunostaining for dopaminergic neurons expressing tyrosine hydroxylase in the locus coeruleus and d tyrosine hydroxylase+ tracts in the CA1 hippocampus with representative western blot analysis on the whole hippocampus for at least n = 5 mice per group. Scale bars, 200 μm (c, d) and 20 μm for inset (c). Data are mean ± s.e.m. *P ≤ 0.05; ***P ≤ 0.001;****P ≤ 0.0001 (unpaired two-sided t-tests (b, c, d))

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