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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease

Fig. 3

Genetic KCa3.1 deletion and pharmacological blockade with senicapoc attenuate MPTP-induced microgliosis. a, c Immunostaining for Iba1 in SNpc. Bar 50 μM. Quantitative analysis of Iba1+ cells in SNpc. Data are presented as mean ± SEM (n = 5–8). *p < 0.05, **p < 0.01, ***p < 0.001. One-way ANOVA followed by the Dunnett’s multiple comparison test. b, d Expression of iNOS, COX-2, TNF-a, IL-6, and IL-1β in SNpc was measured by qPCR. Data are presented as mean ± SEM (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001. One-way ANOVA followed by the Dunnett’s multiple comparison test

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