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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

Fig. 5

The cerebrospinal meninges in the pathogenesis of experimental autoimmune encephalomyelitis, a Th cell-mediated autoimmune disease. a Schematic illustration of the anatomy and histology of cerebrospinal meninges from the neuroimmunological point of view. The communication of the glymphatic system and the cerebrospinal meninges is shown. b The infiltration of pathogenic Th cells into the cerebrospinal meninges before their infiltration into the CNS parenchyma. Ag, antigen; APC, antigen-presenting cell; CSF, cerebrospinal fluid; DC, dendritic cell; FRC, fibroblastic reticular cell; mamo, macromolecules; mo, monocyte; mø, macrophage; MVEC, meningeal vascular endothelial cell; SAS, subarachnoid space; ThE, effector Th cell; TLT, tertiary lymphoid tissue

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