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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

Fig. 7

The dorsal root leptomeninges (DRLMs) as the potential neuroimmune interface for Th cells as a trigger for chronic tactile allodynia after nerve injuries. a Schematic summary of current evidences for the infiltration of CD4+ αβ T cells (most possibly Th cells) along the neuroaxis and functional implications of potential Th cell infiltration in the chronification of tactile allodynia after nerve injuries. b Schematic illustration of the anatomy and histology of DRLMs from the neuroimmunological point of view. Region-specific targeting methods for DRLM CD4+ αβ T cells (most possibly Th cells) are shown: [1] LLNe: prior lymphadenectomy to lumbar lymph nodes (LLNs), where CD4+ αβ T cells in DRLMs are derived [2]; chronic intrathecal injection of the suppressive anti-αβTCR antibodies to specifically deplete CD4+ αβ T cells that selectively infiltrate into DRLMs along the neuroaxis after nerve injuries. c The selective infiltration of CD4+ αβ T cells (most possibly Th cells) into lumbar DRLMs along the neuroaxis after adult rat tibial nerve transection (TNT). Here, only the data about DRLMs around the DRG and proximal DR 7 days after nerve injuries is shown for the sake of clarity. d Chronic intrathecal application of the suppressive anti-αβTCR antibodies, which specifically deplete CD4+ αβ T cells (most possibly Th cells) in DRLMs, reduces the development of chronic tactile allodynia after adult rat TNT

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