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Table 1 Chronic tactile allodynia after nerve injuries in rodents with potential Th cell targeting compared to controls

From: MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

Nerve injuriesPotential techniques for Th cell targetingAnimal species/sexesPain severity vs. controlsReferences
SNIRag1−/−C57BL/6 J mice; MReducedCobos et al. (2018)
Rag1−/− mice reconstituted with WT T cellsRestored
SNIRag2−/−C57BL/6 mice; M + FReducedVicuna et al. (2015)
Rag2−/− mice reconstituted with WT T cellsRestored
CIPN (Paclitaxel)Rag1−/−C57BL/6 J mice; M + FProlongedKrukowski et al. (2016)
Rag1−/− mice reconstituted with CD4+ T cellsUnchanged
CCINudeLewis rat; MReducedMoalem et al. (2004)
Transfer of conditioned Th1-like cells from heterozygous rats into athymic nude ratsRestored
SSNLCD4−/−BALB/c mice;
M
ReducedCao et al. (2008)
CD4−/− mice reconstituted with CD4+ cellsRestored
SSNLCatS inhibitor Z-FL (i.p.)DBA/2 mice;
M
ReducedZhang et al. (2014)
CatS−/−; splenectomyReduced
Transfer of conditioned splenocytes or splenic CD4+ T cells from WT mice into CatS−/− or splenectomized miceRestored
SSNLMHCII−/−C57BL Mice; MReducedSweitzer et al. (2002)
  1. CCI chronic constriction injury, CINP chemotherapy-induced peripheral neuropathy, F female, M male, SNI spared nerve injury, SSNL selective spinal nerve ligation