MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

Table 1 Chronic tactile allodynia after nerve injuries in rodents with potential Th cell targeting compared to controls

Nerve injuries	Potential techniques for Th cell targeting	Animal species/sexes	Pain severity vs. controls	References
SNI	Rag1^−/−	C57BL/6 J mice; M	Reduced	Cobos et al. (2018)
SNI	Rag1^−/− mice reconstituted with WT T cells	C57BL/6 J mice; M	Restored	Cobos et al. (2018)
SNI	Rag2^−/−	C57BL/6 mice; M + F	Reduced	Vicuna et al. (2015)
SNI	Rag2^−/− mice reconstituted with WT T cells	C57BL/6 mice; M + F	Restored	Vicuna et al. (2015)
CIPN (Paclitaxel)	Rag1^−/−	C57BL/6 J mice; M + F	Prolonged	Krukowski et al. (2016)
CIPN (Paclitaxel)	Rag1^−/− mice reconstituted with CD4⁺ T cells	C57BL/6 J mice; M + F	Unchanged	Krukowski et al. (2016)
CCI	Nude	Lewis rat; M	Reduced	Moalem et al. (2004)
CCI	Transfer of conditioned Th1-like cells from heterozygous rats into athymic nude rats	Lewis rat; M	Restored	Moalem et al. (2004)
SSNL	CD4^−/−	BALB/c mice; M	Reduced	Cao et al. (2008)
SSNL	CD4^−/− mice reconstituted with CD4⁺ cells	BALB/c mice; M	Restored	Cao et al. (2008)
SSNL	CatS inhibitor Z-FL (i.p.)	DBA/2 mice; M	Reduced	Zhang et al. (2014)
	CatS^−/−; splenectomy		Reduced
	Transfer of conditioned splenocytes or splenic CD4+ T cells from WT mice into CatS^−/− or splenectomized mice		Restored
SSNL	MHCII^−/−	C57BL Mice; M	Reduced	Sweitzer et al. (2002)

CCI chronic constriction injury, CINP chemotherapy-induced peripheral neuropathy, F female, M male, SNI spared nerve injury, SSNL selective spinal nerve ligation

ISSN: 1742-2094