Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events

Table 3 Biochemical Aβ assessment

Group	Time-point (weeks)	Aβ_1–38		Aβ_1–40		Aβ_1–42
Group	Time-point (weeks)	Soluble	Insoluble	Soluble	Insoluble	Soluble	Insoluble
Control	6	0.03 ± 0.01	12.2 ± 2.8	0.9 ± 0.2	410 ± 95.2	0.7 ± 0.2	619 ± 87.2
	10	0.05 ± 0.03	20.6 4.4	0.4 ± 0.1	550 ± 87.6	0.8 ± 0.3	670 ± 69.5
	14	0.08 ± 0.02	24.8 ± 6.8	0.8 ± 0.6	668 ± 100.1	1.4 ± 0.6	1214 ± 85
	18	0.12 ± 0.06	19.9 ± 8.7	1.5 ± 0.4	942 ± 206	1.2 0.4	1513 ± 97
HHcy	6	0.02 ± 0.01	13.2 ± 1.3	1.1 ± 0.3	570 ± 120.2	0.9 ± 0.3	555 ± 98.7
	10	0.14 ± 0.07	29.6 ± 9.4	0.8 ± 0.2	654 ± 126.4	0.7 ± 0.2	741 ± 59.7
	14	0.09 ± 0.03	22.5 ± 7.6	0.7 ± 0.1	781 ± 154.2	1.4 ± 0.6	1356 ± 96
	18	0.16 ± 0.08	19.6 ± 8.4	0.6 ± 0.2	1150 ± 215	1.5 ± 0.4	1641 ± 79

ISSN: 1742-2094