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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis

Fig. 6

KS23 activates AMPK and suppresses the NF-κB signaling pathway. Groups of B10RIII mice were immunized with R161 to induce EAU and treated with PBS, KS23, or TQ23. n = 5 per group. a Western blot analysis of the expression of AdipoR1, phospho-AMPK, AMPK, SIRT1, PPARγ, RORγt, acetylated p65, and p65 in the retina of EAU mice. The band intensities were assessed using ImageJ. b AdipoR1 expression levels are represented as their ratios compared to β-actin. c phospho-AMPK levels are represented as the ratio of phospho-AMPK to AMPK. df SIRT1, PPARγ, and RORγt expression levels are represented as their ratios compared to β-actin. g. The acetylation level of p65 is represented as the ratio of acetylated p65 to p65. Results are shown as means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001; ns, non-significant

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