Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells

Fig. 2

NK cell adoptive transfer reduced Tfh cells and germinal center B cells in EAMG. Rats were sacrificed at the 46th day post the first immunization, and the spleens were collected. The following results were representatives of two independent experiments. a Frequencies of Tfh cells (CD4+CXCR5+ICOS+) among splenic CD4+ cells were downregulated by NK cell treatment. b Frequencies of germinal center B cells (B220+PNA+) among splenocytes were downregulated after NK cell adoptive transfer. c B cell (B220+) frequencies but not memory B cell (B220+CD27+) frequencies among splenocytes were reduced after NK cell adoptive transfer. d NK cell adoptive transfer did not change IFN-γ+ (Tfh1) or IL-17+ (Tfh17) cell frequencies among Tfh cells (CD4+CXCR5+ICOS+). e Frequencies and phenotypes of splenic DCs after NK cell treatment in EAMG. Dendritic cells were gated as CD103+MHC II+. The phenotypes of DCs referred to CD80, CD86, and MHC II expression levels, which were shown as MFI (mean fluorescent intensity). Data were presented as mean ± SEM. Unpaired Student’s t test was used. ns means not significant, *p < 0.05, **p < 0.01

Back to article page