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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells

Fig. 6

Different roles of CXCR5- and CXCR5+ NK cells in regulating Tfh cells. a, b Correlation analysis of Tfh cell frequencies (among CD4+ T cells) with the frequencies of CXCR5+ NK cells (left) or the ratios of CXCR5- to CXCR5+ NK cells (right) in rat EAMG (a) and EAN (b) models. Spearman correlation test was used. One-independent experiment. c Correlation analysis of germinal center B cell frequencies (among splenocytes) with the frequencies of CXCR5+ NK cells (left) or the ratios of CXCR5- to CXCR5+ NK cells (right) in rat EAMG. Spearman correlation test was used. One-independent experiment. d, e Mouse splenocytes were co-cultured with CXCR5- and CXCR5+ NK cells. CD4+ T cells (d) and Tfh (e) cell numbers were counted by flow cytometry and shown as relative forms. Data were presented as mean ± SEM. Two independent experiments. One-way ANOVA. *p < 0.05. fh Splenic CD3+ T were co-cultured with CXCR5- and CXCR5+ NK cells for three days and analyzed by flow cytometry. MFI means mean fluorescent intensity. Data were presented as mean ± SEM. Two independent experiments. One-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001

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