Fig. 8

TREM-2 knockdown enhanced while TREM-2 overexpression inhibited pro-inflammatory cytokines in high glucose-hypoxia-stimulated microglia by targeting p38 MAPK. a Representative bands of Western blot data. b Quantitative analysis of the Western blot bands. c, d The mRNA expression of pro-inflammatory cytokines (IL-1β, TNF-α, iNOS, and COX2) was detected by RT-PCR. **P < 0.01; ***P < 0.001 vs. the BV2 cells (Normal); ^#P < 0.05; ^##P < 0.01; ^###P < 0.001 vs. the BV2 cells (hypoxia and high glucose)