The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction

Table 2 Predictors of poor outcome identified in the univariate analysis and results of backward elimination models

	Univariate analysis			Multivariate analysis of individual cytokines adjusted for age and stroke severity			Multivariate analysis of all cytokines adjusted for age and stroke severity
	OR	95% CI	p value	OR	95% CI	p value	OR	95% CI	p value
Age	1.04	1.02–1.06	<0.01	1.04	1.02–1.06	<0.01	1.03	1.01–1.06	0.01
NIHSS on admission	1.12	1.07–1.16	<0.01	1.12	1.07–1.17	<0.01	1.09	1.04–1.14	<0.01
Cytokines*
Ex vivo stimulation
IL-12p70	0.46	0.31–0.67	<0.01	0.50	0.34–0.74	<0.01	0.55	0.36–0.84	<0.01
IL-10	1.55	1.17–2.05	<0.01	1.49	1.11–2.00	<0.01	1.83	1.32–2.56	<0.01
IL-1β	0.69	0.52–0.90	<0.01	0.74	0.55–0.99	0.04	0.85	0.60–1.20	0.36
IL-8	1.75	1.22–2.51	<0.01	1.54	1.06–2.22	0.02	1.28	0.80–2.05	0.31
TNFα	0.62	0.46–0.84	<0.01	0.67	0.49–0.92	0.01	0.64	0.44–0.92	0.02
IP-10	0.61	0.44–0.84	<0.01	0.65	0.47–0.90	0.01	0.89	0.59–1.34	0.58
Plasma
IL-6	2.68	1.64–4.39	<0.01	1.86	1.17–2.94	< 0.01	1.59	1.02–2.47	0.04

*Cytokines were standardized to the same scale (mean = 0; SD = 1)
NIHSS – National Institutes of Health Stroke Scale; OR- odds ratio; 95% CI- 95% confidence interval

ISSN: 1742-2094