Fig. 1

In vivo PET imaging of TSPO using [¹¹C]PBR28. Representative summed images from the dynamic reconstruction of simultaneously acquired PET/CT scans from 10-week-old male Wistar rats subjected to experimental meningitis and controls, 60 min after intravenous injection of [¹¹C]PBR28. The coronal, sagittal, and dorsal orientations of the brain are presented, showing increased brain [¹¹C]PBR28 uptake in the experimental meningitis model than in controls. a Twenty-four hours after experimental meningitis induction. b Ten days after experimental meningitis induction. The SUV scale represents the standardized uptake value (SUV). Quantification of [¹¹C]PBR28 uptake detected in the experimental meningitis model was significantly higher than that in the controls based on measures of brain/muscle. c SUV 24 h after experimental meningitis induction. d SUV 10 days after experimental meningitis induction. The results are expressed as the mean ± SEM for n = 5–8 rats. *P < 0.05, **P < 0.01 compared to controls