Fig. 10

Upregulation of the expression of the neuroimmunomodulatory target TSPO 10 days after experimental meningitis induction in the PFC and hippocampus. Western blot analysis of the tissue protein levels of mitochondrial protein. Quantification of the immunoblot data using the densitometric analysis of each protein was carried out using Image Lab™ software (Bio-Rad, CA, USA). Representative immunoblots and the quantification of TSPO, VDAC, ANT, cytochrome-c and loading controls, COX IV, and β-tubulin in PFC (a–e) and hippocampus (f–j). The values of all protein levels were normalized to COX IV or β-tubulin levels. The results are expressed as the mean ± SEM for n = 4–5 rats. *P < 0.05 compared to controls