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Table 1 Increased inflammatory mediator levels 24 h after experimental meningitis induction in the PFC and hippocampus. The results are expressed as the mean ± SEM for n = 5–6 rats

From: Neuroinflammation trajectories precede cognitive impairment after experimental meningitis—evidence from an in vivo PET study

Cytokines (pg/ÎĽg)

PFC—24 h

Hippocampus—24 h

Control

Meningitis

Control

Meningitis

IL-1a

0.018 ± 0.001

0.711 ± 0.222*

0.014 ± 0.001

0.199 ± 0.020*

IL-1β

0.165 ± 0.009

1.569 ± 0.256*

0.107 ± 0.008

0.267 ± 0.027*

IL-4

0.009 ± 0.001

0.007 ± 0.001

0.005 ± 0.0004

0.005 ± 0.0009

IL-5

0.052 ± 0.003

0.046 ± 0.009

0.034 ± 0.002

0.315 ± 0.003

IL-6

0.077 ± 0.005

0.984 ± 0.030*

0.059 ± 0.005

0.447 ± 0.050*

IL-7

0.010 ± 0.0007

0.007 ± 0.0008*

0.003 ± 0.0002

0.002 ± 0.0008

IL-10

0.033 ± 0.004

0.019 ± 0.001*

0.022 ± 0.001

0.023 ± 0.001

IL-12

0.013 ± 0.001

0.006 ± 0.008

0.009 ± 0.001

0.009 ± 0.0008

IL-13

0.027 ± 0.001

0.012 ± 0.0008*

0.012 ± 0.0008

0.011 ± 0.001

IL-17

0.021 ± 0.002

0.041 ± 0.001*

0.011 ± 0.0002

0.014 ± 0.001

IL-18

0.037 ± 0.003

0.050 ± 0.006

0.031 ± 0.002

0.043 ± 0.003*

TNF-α

0.054 ± 0.004

0.312 ± 0.029*

0.041 ± 0.005

0.059 ± 0.003*

INF-Îł

0.021 ± 0.002

0.070 ± 0.006*

0.023 ± 0.002

0.069 ± 0.006*

  1. *P < 0.05 compared to controls