Fig. 5
From: Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
LAM treatment significantly decreased Dectin-1 and p-Syk expression. a, b Dectin-1, Syk and p-Syk expression was significantly enhanced in the brain tissue in the ischemia and ischemia + saline groups compared with that of the sham group. However, LAM treatment significantly decreased Dectin-1 and p-Syk expression in the ischemia group (n = 3/group; *P < 0.05 vs. sham group; #P < 0.05 vs. ischemia group/ischemia + saline group). c, d The Dectin-1, Syk, and p-Syk expression levels were significantly increased in BV2 cells subjected to OGD/R for 3 h compared with that of the BV2 cells without OGD/R exposure. However, LAM pretreatment significantly attenuated Dectin-1 and p-Syk expression in the BV2 cells subjected to the OGD/R 3 h injury model (n = 3/group; *P < 0.05 vs. control group; #P < 0.05 vs. OGD/R 3 h group)