Skip to main content
Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice

Fig. 8

PIC treatment attenuated p-Syk expression in ischemic brain tissue and in BV2 cells with OGD/R exposure. a, b p-Syk expression was significantly enhanced in the ischemic brain tissue in the ischemia and ischemia + DMSO groups compared with that of the sham group. PIC treatment significantly decreased p-Syk expression in the ischemic brain tissue (n = 3/group; *P < 0.05 vs. sham group; #P < 0.05 vs. ischemia group/ischemia + DMSO group). However, PIC treatment failed to decrease Dectin-1 expression in the ischemic brain tissue. c, d Dectin-1 and p-Syk expression in BV2 cells with OGD/R exposure was significantly increased compared with that of the cells without OGD/R exposure. PIC pretreatment of BV2 cells with OGD/R exposure significantly decreased p-Syk expression (n = 3/group; *P < 0.05 vs. control group; #P < 0.05 vs. OGD/R group). However, Dectin-1 expression was not attenuated in the OGD/R-induced BV2 cells with PIC treatment compared with that of the OGD/R-induced BV2 cells without PIC pretreatment.

Back to article page