Fig. 4
From: Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Microglial modulation of actin network for engulfment and migration. a, b Microglia, upon Tau aggregate treatment, formed increased fan-shaped lamellipodia-like actin structure at the site of growth and movement while oligomer-treated group has shown with only micro-spike actin extensions called filopodia, which may signify the initiation process of phagocytosis. c Microscopic quantification depicted the increase of actin intensity in microglia upon oligomer and aggregate exposure, but when normalized with a cellular surface area, the actin levels were non-significantly altered. d These results signified only the remodeling of the actin network in lamellipodia-like and podosome-like migratory structures for phagocytic clearance of Tau overburden. Significant at the mean difference between treatment groups (X − X`) > Tukey’s criterion (T)