Fig. 5
From: Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Actin-mediated activation of microglia by Tau oligomers. a, b N9 microglia showed an increased level of Iba1 in hTau40WT oligomer-treated group as compared to aggregate exposure by western blot. Significant at the mean difference between treatment groups (X − X`) > Tukey’s criterion (T). The # sign corresponds to non-significant by Tukey’s test. c The immunostaining study revealed the accumulation of Iba1 with remodeled actin structures at the rear end of activated migratory microglia. The localization of Iba1 at the rear site of microglia may emphasize the contraction of the actin network for mediating forward movements during migration. The “arrow” has represented the migratory direction in front ends and the retraction of actin structures containing Iba1 from rear ends in N9 cells