Fig. 10From: Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging miceGeneral overview of the main highlights of this study. Anesthesia and surgery-induced neuroinflammation overactivated NMDARs and calpain, which subsequently led to the truncation of TrkB-FL, BDNF/TrkB signaling dysregulation, dendritic spine loss, and cell apoptosis, contributing to cognitive impairments in aging miceBack to article page