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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

Fig. 5

MEM treatment reduced the cleavage of TrkB by modulating the overactivation of calpain on day 1 post-surgery. a Representative Western blots of SBDP in the hippocampus. GAPDH was included as loading control. b Quantitative analysis of the ratio of the SBDP to αII-spectrin. c Representative Western blots of TrkB-FL. GAPDH was included as loading control. d Quantitative analysis of TrkB-FL levels. e Representative Western blots of TrkB-ICD. β-tubulin was included as loading control. f Quantitative analysis of TrkB-ICD levels. Data are presented as the mean ± SEM (n = 6). *p < 0.05 compared to the con + veh group (**p < 0.01, ***p < 0.001), #p < 0.05 compared to the sur + veh group (##p < 0.01, ###p < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094