Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

Table 1 Prior research—stimulated areas and activated brain regions studied

Study	Stimulated area	Activated brain regions^a
Yakunina et al. (2017) [72]	The inner tragus and cymba conchae and the inferior posterior wall of the auditory canal	The NTS and the LC
Kraus et al. (2007) [46]	The left outer auditory canal	Increased activation in the insula, precentral gyrus, and thalamus; decreased activation in the amygdala, hippocampus, parahippocampal gyrus, and middle and superior temporal gyrus
Kraus et al. (2007) [46]	The posterior wall	The NTS
Kraus et al. (2013) [44]	The anterior left auditory canal	The parahippocampal gyrus, PCC, and right thalamus (pulvinar), NTS, and LC
Dietrich et al. (2008) [45]	The left inner tragus	The left LC, thalamus, left prefrontal cortex, right and left postcentral gyrus, left posterior cingulate gyrus, and left insula, as well as decreased activation in the right nucleus accumbens and right cerebellar hemisphere
Badran et al. (2018) [54]	The left tragus (active) or earlobe (control)	The contralateral postcentral gyrus, bilateral insula, frontal cortex, right operculum, left cerebellum and the right caudate, bilateral anterior cingulate, cerebellum, left prefrontal cortex, and middle cingulate
Frangos et al. (2015) [14]	The cymba conchae	Increased activation in the ipsilateral NTS, bilateral spinal trigeminal nucleus, dorsal raphe, LC, contralateral parabrachial area, amygdala, nucleus accumbens, bilateral paracentral lobule; decreased activation in the bilateral hippocampus and hypothalamus

LC locus coeruleus, NTS nucleus tractus solitaries, PCC posterior cingulate cortex
^aIn healthy participants

ISSN: 1742-2094