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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis

Fig. 1

Clozapine treatment reduces infiltration into the CNS during the onset of EAE. C57BL/6 female mice were treated with clozapine (60 mg/kg/day) or vehicle control in their drinking water commencing one day prior to immunization and were scored daily (a, b). At day 5, 7, 9, and 11 after EAE induction spinal cord (cf), brain (gj), spleen (kn), and blood (or) was collected and cell numbers were analyzed by flow cytometry. Shown are the means and SEM of individual mice (n = 9/treatment group) from three independent experiments normalized to healthy vehicle for each day. *p < 0.0332, **p < 0.021, and ***p < 0.0001 by two-way ANOVA with Tukey’s multiple comparisons test comparing EAE vehicle versus EAE Clozapine. ###p < 0.0002 and ###p < 0.0001 by three-way ANOVA comparing healthy versus EAE

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