Fig. 3

Proliferating SVZ progenitors produce oligodendrocytes that contribute to corpus callosum remyelination in the TMEV-IDD model. a, b Scheme of the intraventricular administration of the SFFV-Venus retroviral vectors at the onset of corpus callosum remyelination to track the labeled, proliferating progenitors in the SVZ. c Green Venus⁺ cells can be found in the remyelinated corpus callosum at 27 days p.i. The oligodendroglial identity of these cells, with a typical branched myelinating morphology, was evaluated by immunostaining, showing that they are negative for the OPC marker NG2, and positive for the mature oligodendrocyte markers Olig2 and CC1. Scale bar: 25 μm. Images are representative of three independent experiments