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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis

Fig. 9

Myelin debris and M2c microglia contribute to oligodendrocytes generation from dorsal SVZ stem cells. Coronal mouse brain reflecting the capacity of the corpus callosum and dorsal SVZ to generate oligodendrocytes via environmental signals. The myelin debris generated during demyelination provokes microglial activation towards the phagocytic M2c state that secretes the Wnt7a protein. The Wnt7a/β-Catenin pathway drives the specification of dorsal SVZ stem cells towards an oligodendrocyte intermediate progenitor cell (oIPC) fate, committed to the oligodendroglial lineage. Conversely, myelin debris directly affects the specification and differentiation of oIPCs towards mature oligodendrocytes. Oligodendrogenesis may not only be mediated by the mobilization and differentiation of local OPCs but also, by the specification and differentiation of stem cells in the dorsal SVZ through the activity of M2c microglia and the collateral effects of the myelin debris generated during demyelination

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