Fig. 4
From: Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
Zymosan-induced neurotoxicity is mediated by the brain microglia. a Staining of cortical sections from 5xFAD brain showed that TLR2 immune-reactivity co-localized with Iba1+ microglia. There were rare cells with neuron-like morphology that also expressed TLR2. b Experimental time line of minocycline treatment and zymosan injection. c Quantification of cortical neurons showed that minocycline treatment did not affect neuronal counts, but abolished the neurotoxic effect induced by ICV injection of zymosan. Dashed line represents the baseline NeuN count of untreated wt (blue) and 5xFAD (orange) mice. *ANOVA f (3, 20) = 22.093, p < 0.001