Fig. 7From: Suppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root gangliaThe effects of SAHA on TCI-induced neuroinflammation in the dorsal root ganglia. a Immunofluorescent staining of HDAC1 (green), HDAC2 (green), and GFAP (red) in the dorsal root ganglia of the Sham + vehicle, the TCI + vehicle, the TCI + SAHA, and the Sham + SAHA group on POD 21. Scale bar = 100 μm. Representative bands (b) and quantitative analysis of HDAC1, HDAC2, GFAP, TNF-α, IL-1β and IL-6 (c) in the dorsal root ganglia of Sham + vehicle, the TCI + vehicle, the TCI + SAHA and the Sham + SAHA group (n = 4). Analysis was based on the mean gray values and normalized to β-actin. Data are expressed as mean ± SEM. *p < 0.05 and ***p < 0.001 versus the Sham + vehicle group, and  ##p < 0.01, ###p < 0.001 versus the TCI + vehicle groupBack to article page