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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Fig. 1

Experimental protocol. Three-month-old APP/PS1 mice or C57BL/6 mice received five injections. The animals were intramuscularly (i.m.) injected with IIV or PBS every 4 weeks over a 5-month period. Three weeks after the final injection, the MWM and OFT were conducted to assess the spatial learning and memory and spontaneous locomotor activity of the mice. Then, tissues were collected for the subsequent experiments at the age of 8 months. At the age of 7 months, the AD+IIV mice were i.p. injected with ATRA or DMSO 5 times every other day and tested as previously described

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Journal of Neuroinflammation

ISSN: 1742-2094