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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Fig. 5

IIV treatment altered T cell homeostasis and reversed excessive CD4+Foxp3+ Tregs activity in APP/PS1 mice. a Representative flow cytometry plots and quantitative analysis of the proportions of CD4+Foxp3+ Treg splenocytes reflecting that the frequencies of Tregs in the AD mice were higher than those in the WT mice, while the IIV treatment reversed the excessive Treg accumulation (n > 10, mean ± SEM, one-way ANOVA and LSD post hoc test, *P < 0.05). b–d Intracellular staining of CD4+ splenocytes producing IFN-γ (b), IL-4 (c), and IL-17A (d) is presented as flow cytometry plots, and the quantitative analysis of each cytokine is shown on the right (n > 5, mean ± SEM, one-way ANOVA and LSD post hoc test)

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