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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Fig. 7

Enhanced immune suppression reversed IIV-induced improvement in Aβ pathology. a Representative microscopic images of the cortex and hippocampus of the AD, AD+IIV, IIV+ATRA and IIV+Vehicle mice stained for Aβ (purple) and Hoechst nuclear staining (blue) (scale bar, 200 μm). b, c Quantification of the percentage of the surface area and numbers of Aβ plaques was performed in five equidistant slices separated by 240 μm per animal (n = 9, mean ± SEM, one-way ANOVA and LSD post hoc analysis, *P < 0.05, **P < 0.01, ***P < 0.001). df ELISA was utilized to analyze the levels of soluble and insoluble Aβ1-40 and Aβ1-42 extracted with RIPA (i), SDS (j), and FA (k) from the cerebral cortex of 8-month-old APP/PS1 mice (n = 5, mean ± SEM, One-way ANOVA and LSD post hoc analysis, *P < 0.05, **P < 0.01)

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