The association between serum adipocyte fatty acid–binding protein and 3-month disability outcome after aneurysmal subarachnoid hemorrhage

Table 3 Multivariate logistic regression analysis for poor outcomes according to FABP4 quartiles

FABP4^a	Poor/N (%)	Crude OR (95% CI), P^#	Multivariable-adjusted^b, P^#
Quartile 1	10/107 (9.3)	Reference	Reference
Quartile 2	23/105 (21.9)	2.72 (1.22–6.05), 0.012	1.92 (0.93–5.93), 0.072
Quartile 3	28/102 (27.5)	3.67 (1.68–8.03), 0.001	2.75 (1.55–6.03), 0.021
Quartile 4	54/104 (51.9)	10.48 (4.92–22.31), < 0.001	5.68 (2.83–10.02), < 0.001
Elevated vs. normal	82/206 vs. 33/212	3.79 (2.38–6.02), < 0.001	2.89 (1.60–6.15), 0.009

OR odds ratio, CI confidence interval, CRP C-reactive protein, APACHE-II 5 Acute Physiology and Chronic Health Evaluation II, IVH intraventricular hemorrhage, DCI delayed cerebral ischemia, ICH intracerebral hemorrhage, CRP C-reactive protein, TCD transcranial Doppler, H-H Hunt–Hess
^aFABP4 in quartile 1 (< 12.5 ng/ml), quartile 2 (12.5–18.2 ng/ml), quartile 3 (18.3–24.9 ng/ml), and quartile 4 (> 24.9 ng/ml). Elevated FABP4 level was defined as ≥ 24.9 ng/ml (3rd quartile)
^bAdjusted for those significant risk factors which confirmed in the univariate analysis (Table 2), including age, hypertension, cardiovascular comorbidities, a history of nicotine abuse, surgical clip, coiling, complications in the study, H-H score, aneurysm size > 10 mm, APACHE-II score, IVH sum score, hydrocephalus, cerebral vasospasm, DCI, glucose, and CRP
^#P value for the trend < 0.001

ISSN: 1742-2094