Fig. 8
From: Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway
Analysis of the TNF-a-TNFR1-NF-κB pathway after 2 weeks of hyperammonemia. The effects of R7050 treatment on TNF-a expression in microglia (a, c) and astrocytes (b, d) and on NF-kB p50 nuclear translocation in Purkinje neurons (e, h), microglia (f, i) and astrocytes (g, j) after 2 weeks of hyperammonemia are shown. The values are the mean ± SEM of 3 rats per group. Values that were significantly different from those of the control rats are indicated by asterisks, and values that were significantly different from those of HA VH rats are indicated by a. *p ≤ 0.05, **p ≤ 0.01, a < 0.05, and aa p ≤ 0.01. C VH = cerebellar slices obtained from vehicle-treated control rats; C + R7050 = cerebellar slices obtained from control rats and incubated with R7050; HA VH = cerebellar slices obtained from vehicle-treated hyperammonemic rats, HA + R7050 = cerebellar slices obtained from hyperammonemic rats and incubated with R7050