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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

Fig. 9

TNF-a and nuclear NF-kB are not increased in hyperammonemic rats at 1 week. Representative images of TNF-a expression and nuclear NF-kB in Purkinje neurons (a, f, respectively), microglia (b, g, respectively), and astrocytes (c, h, respectively) are shown. The content of TNF-a and the nuclear/cytoplasmic ratio of the p50 subunit of NF-kB are quantified in d and i, respectively. e The percentage of microglia vs astrocytes expressing TNF-a. The numbers of microglia and astrocytes expressing nuclear p50 are quantified in j and k, respectively. C VH = vehicle-treated control rats, HA VH = vehicle-treated hyperammonemic rats

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