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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury

Fig. 6

Intrathecal ODN 2088 treatment increases the percentage of F4/80+/Arg-1+ double-labeled cells at the glial scar following SCI. Representative fluorescent images showing horizontal SC sections of mice that sustained a SCI and treated with a vehicle and b ODN 2088. The images were obtained from the glial scar. The sections were double-labeled with an antibody against F4/80 (green) and Arg-1 (red), and counter stained with DAPI (blue). Arrows point at examples of F4/80+/Arg-1+ double-labeled cells. Scale bar: 20 μm. c Percentage of F4/80+/Arg-1+ double-labeled cells within the 500-μm-wide zone immediately adjacent to the rostral border of the lesion core [***p < 0.001, independent-sample t-test, two-tailed]. d Percentage of F4/80+/Arg-1+ double-labeled cells within the 500-μm-wide zone immediately adjacent to the rostral border of the lesion core [**p < 0.01, independent-sample t-test, two-tailed]. Data are presented as mean ± SEM. n = 4 mice/group

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Journal of Neuroinflammation

ISSN: 1742-2094