Fig. 1

Weight change, organ weight changes, and mouse survival. a Shows the weights of P301S transgenic mice (P301S) and wild-type mice (WT) when combining homotypic male and female mice into a single group, respectively. Significant effect was observed between P301S and WTs. Data are presented as mean ± S.E.M. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. b Shows the weight changes of the four groups of mice. c to g shows the weight changes of lung, spleen, liver, heart, and kidney in each subgroup in the observation period, respectively. Significant effects were observed between sex-and age- matched P301S and WTs. Data are presented as mean ± S.E.M. *p < 0.05, **p < 0.01. h Shows the survival of the four groups during 1-year period. The line in (b to h): blue: P301S MALE, red: P301S FEMALE, green: WT MALE, purple: WT female