Fig. 6

Changes in human total tau, inflammatory cytokines, and chemokines in mouse plasma. a Shows the concentration changes in human total Tau in plasma of four groups of mice between 3 and 12 months old. Line graph shows in mean ± S.E.M. b–i Show the concentration changes of MIP-3α, IFN-γ, IL-5, IL-6, MIG, TNF-α, IL-10, and IL-13 in RAB fraction of brain homogenates in the four groups. Data are presented as mean ± S.E.M. j Shows the concentration changes in plasma of the 21 factors listed in the left column of the heat map with increasing age of the four groups of mice. The unit of the legend shown on the right of the heat map is pg/mL. The two white squares show the concentration of LIX in the 3 and 4 months old P301S male mice exceeding 3000 pg/mL. The average concentrations in 3 and 4 months old of LIX were 3987.78 pg/mL and 3782.48 pg/mL, respectively