Table 2 Post hoc models

Age

X

X

X

X

X

X

Sex

X

X

X

X

X

X

ApoE ε4 allele (number)

X

X

X

X

X

X

Years of education

X

Baseline MMSE

X

X

X

X

X

Baseline EF

X

X

X

X

X

X

Baseline brain parenchymal volume (cross-sectional)

X

X

X

X

X

Baseline white matter hyperintensity volume

X

X

X

X

X

X

Baseline hippocampal volume (cross-sectional)

X

Acetylcholinesterase inhibitor use

X

X

X

X

X

X

Memantine use

X

X

X

X

X

X

Anti-inflammatory (corticosteroid, NSAID, and ASA 81 mg)

X

X

X

Corticosteroid use

X

NSAID use

X

ASA 81 mg use

X

Markers included in model

NGAL, MPO, IL-8, MIP-1β, TNF

NGAL, MPO, IL-8, MIP-1β, TNF

NGAL, MPO, IL-8, MIP-1β, TNF

NGAL, MPO, IL-8, MIP-1β, TNF

NGAL, MPO, IL-8, MIP-1β, TNF

NGAL, MPO, IL-8, MIP-1β

Model fit indices

X²p value 0.6402, RMSEA 0.000, RMSEA p value 0.947, CFI 1.000, TLI 1.033, SRMR 0.078

X²p value 0.5295, RMSEA 0.000, RMSEA p value 0.854, CFI 1.000, TLI 1.012 SRMR 0.084

X²p value 0.5819, RMSEA 0.000, RMSEA p value 0.930, CFI 1.000, TLI 1.012, SRMR 0.078

X²p value 0.5088, RMSEA 0.000, RMSEA p value 0.904, CFI 1.000, TLI 1.006, SRMR 0.079

X²p value 0.6964, RMSEA 0.000, RMSEA p value 0.961, CFI 1.000, TLI 1.045, SRMR 0.079

X²p value 0.6774, RMSEA 0.000, RMSEA p value 0.940, CFI 1.000, TLI 1.042, SRMR 0.073

Sample size

109

81

109

109

109

109

Effect of baseline neutrophil factor on follow-up executive function (standardized β [95% confidence interval], p value)

β = − 0.152 [− 0.274, − 0.029], p = 0.015

β = − 0.146 [− 0.288, − 0.003], p = 0.045

β = − 0.134 [− 0.273, − 0.011], p = 0.033

β = − 0.131 [− 0.252, − 0.009], p = 0.036

β = − 0.138 [− 0.252, − 0.009], p = 0.026

β = − 0.137 [− 0.267, − 0.007], p = 0.039