Fig. 4

Inflammation-related gene expression in rTg-DI rat brains. Total RNA was extracted from 3 and 12 months old rTg-DI rats and wild-type rats followed by reverse transcription and real-time PCR analysis of marker gene expression was performed using β-actin as an internal control. Gene expressions in wild-type animals were normalized to 1 (dash line). Data presented are the means ± SD of n = 3–5 rats per group. *P < 0.05, **P < 0.01, ***P < 0.001