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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

Fig. 5

Loss of perivascular pericytes in rTg-DI rats. a–l Brain sections from 3-month-old wild-type (a–c) and rTg-DI (d–f) rats and 12-month wild-type (g–i) and rTg-DI (j–l) rats were labeled with Amylo-Glo to detect fibrillar amyloid (blue), rabbit polyclonal antibody to collagen IV to detect cerebral microvessels (red), and goat polyclonal antibody to PDGFRβ for pericytes (green). Scale bars = 50 μm. m, n Enlarged images of the highlighted regions of panels i and l, respectively. Scale bars = 10 μm. o Quantitation of pericyte numbers from wild-type rats (black bars) and rTg-DI rats (gray bars) in different brain regions at 3 and 12 months of age. Data shown are mean ± SD of n = 3–5 rats per group. Pericyte numbers on capillaries increased in wild-type rats in all brain regions as they aged from 3 to 12 months. **P < 0.002. In contrast, pericyte numbers markedly decreased in rTg-DI rats in all brain regions as they aged from 3 to 12 months. ***P < 0.001

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