Fig. 3

Bone marrow chimera mice transplanted with Sema4A KO cells exhibit amelioration of EAE disease activity. BM chimera mice were generated by transplanting WT or Sema4A KO CD45.1 BM cells to CD45.2 WT or Sema4A KO mice (WT → WT, WT → Sema4A KO, Sema4A KO → WT), and adoptively transferred with WT MOG-specific Th17 cells. WT → Sema4A KO recipient mice showed comparable clinical score to WT → WT recipient mice. By contrast, Sema4A KO → WT recipient mice showed amelioration of EAE clinical score. Data are expressed as means ± SEM. *P < 0.05