Sema4A high (≥ 2500 U/ml) (n = 63) | Sema4A low (< 2500 U/ml) (n = 138) | P | |
---|---|---|---|
Female/male (% female) | 51/12 (81.0) | 112/26 (81.2) | 0.972 |
Age at onset (mean ± SD, years) | 28.8 ± 8.4 | 34.8 ± 9.7 | 0.00004* |
Disease duration from onset to examination (mean ± SD, years) | 6.3 ± 8.5 | 8.1 ± 6.9 | 0.125 |
Sema4A (mean ± SD, U/mL) | 26,003.7 ± 108,879.5 | 439.9 ± 635.2 | – |
Positive ratio of OCB (n/N, (%)) | 29/46 (63.0) | 54/104 (51.9) | 0.207 |
Distribution of MRI lesions (n/N, (%)) | |||
- Cerebrum | 59/62 (95.2) | 129/138 (93.5) | 0.643 |
- Cerebellum | 10/60 (16.7) | 25/138 (18.1) | 0.806 |
- Brain stem | 27/62 (43.5) | 72/138 (52.2) | 0.259 |
- Spinal cord | 45/61 (73.8) | 93/137 (67.9) | 0.405 |
- Optic nerve | 22/61 (36.1) | 45/136 (33.1) | 0.683 |
EDSS change before Sema4A analysis (mean ± SD, /year) | 0.7 ± 0.5 | 0.4 ± 0.5 | 0.01* |
ARR before Sema4A analysis (mean ± SD, /year) | 1.13 ± 0.94 | 0.83 ± 0.74 | 0.04* |