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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

Fig. 5

Diet rich in microbiota-accessible carbohydrate inhibited PTP1B and improved synaptic signaling molecules in the hippocampus of diet-induced obese mice. a Protein level of PTP1B in the hippocampus (n = 6). b–d Protein levels of p-IRS-1/IRS-1, p-Akt/ Akt, and p-GSK3β/ GSK3β (n = 6). e Protein level of p-Tau/Tau in the hippocampus (n = 4). f Phosphorylation cascade of insulin IRS-pAKT-pGSK3β-pTau synapse signaling. Values are mean ± SEM. *p < 0.05 vs. Control (Con). #p < 0.05 vs. high-fat and fiber-deficient (HF-FD)

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Journal of Neuroinflammation

ISSN: 1742-2094