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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

Fig. 1

Characterizing ES effects on hippocampal GFAP expression in different developmental stages of WT mice. Representative images of GFAP expression in the HPC of P9 CTL (a) and ES (b) mice. Insets depict GFAP+ cells at 100x magnification in the SLM. At P9, ES does not affect GFAP coverage in the CA (c) but increases GFAP coverage in the SLM (d). No differences in GFAP+ cell density (e) or GFAP+ cell complexity (f) were found in the SLM region. Representative images of GFAP expression in the HPC of 6-month CTL (g) and ES (h) mice. Insets depict GFAP+ cells at × 100 in the SLM. GFAP coverage is not affected by ES at this age in the CA (i) and SLM (j). No differences in GFAP+ cell density (k) or GFAP+ cell complexity (l) were found in the SLM region. Statistical analyses were performed using independent t tests for GFAP coverage and cell density and repeated measures ANOVA for cell complexity. *Significant effect of condition p < 0.05; scale bars: representative images 250 μm, inset images 12.5 μm

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