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Table 1 Effects of BM and adjuvant therapy with vitamin B12 on sulfur amino acids and their metabolites in the hippocampus

From: Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

  Concentrations in groups (μmol/g of protein) P values (2-way ANOVA)
Sh-Sal Sh-B12 Infect-Sal Infect-B12 Effect of BM Effect of vitamin B12 Interaction
Hcy 0.34 ± 0.13 0.33 ± 0.08 0.79 ± 0.49 0.74 ± 0.38 0.0053 0.8286 0.9079
Cys 1.66 ± 0.63 1.8 ± 0.46 2.85 ± 1.4 2.13 ± 0.67 0.0530 0.4447 0.2623
Total GSH 4.94 ± 1.47 5.41 ± 0.46 4.13 ± 1.41 3.29 ± 1.15* 0.0041 0.6975 0.1698
Reduced GSH 3.72 ± 0.97 3.98 ± 0.52 2.98 ± 0.94 2.57 ± 1.05 0.0052 0.8268 0.3451
  1. Data are expressed as means ± S.D. Statistical differences were assessed using a 2-way ANOVA (Bonferroni post hoc test) to examine the effects of meningitis and adjuvant therapy with vitamin B12.
  2. *Statistically significant differences (P < 0.05) at Bonferroni post hoc test when compared with the respective sham-infected control (Sh-Sal or Sh-B12)
  3. Sh-Sal sham-infected + saline, Sh-B12 sham-infected + vitamin B12, Infect-Sal infected + saline, Infect-B12 infected + vitamin, B12Hcy homocysteine, Cys cysteine, GSH glutathione